Evidence-Based Optimization Stack
Tim Ferriss's refined supplement stack based on 15+ years of self-experimentation. Features his Momentous Performance Stack partnership, evolved AGG protocol, and evidence-based compounds for cognitive performance, sleep optimization, and recovery. Updated from his September 2025 Q&A and recent partnerships.
Last Updated: Oct 1, 2025
Tim's #1 supplement since 2010. All-in-one nutritional insurance with 75+ nutrients. $99/month or $3/day
2 capsules. 24 probiotic strains + prebiotic. Tim noted improved digestion and skin tone vs other probiotics
600mg for liver support and glutathione production. Especially when traveling for antioxidant protection
1-2 tbsp for cognitive enhancement and ketone production. Particularly useful during suboptimal sleep periods
5g Creapure from Germany (not China). Tim uses primarily for mental performance and short-term memory. NSF certified
600mg daily from AGG protocol (evolved PAGG). Antioxidant support especially when using ketone esters
400mg for antioxidant and metabolic benefits. Third component of AGG protocol replacing original PAGG
Support for hormonal and reproductive health. Based on research findings Tim mentioned in recent protocols
3000-5000 IU for hormone support and immune function. Dosage based on blood levels
Zinc, lutein, zeaxanthin for eye health and longevity protocol. Preventative measure for family history concerns
20g grass-fed protein with ProHydrolase enzymes. Part of Tim's Performance Stack. Use code TIM for 35% off
144mg elemental magnesium from 2g Magtein. Only form that crosses blood-brain barrier effectively for sleep and cognition
50mg chamomile-derived compound for sleep initiation. Part of Tim's sleep stack. GABA channel agonist
200mg for anti-anxiety and relaxation. Completes Tim's 3-part sleep stack with magnesium and apigenin
Part of AGG protocol. Cardiovascular health and immune support. Taken with meals for absorption
500mg as natural metformin alternative for blood sugar control and metabolic health
1000mg EPA/DHA supercritical CO2 extracted. Tested for purity by Kevin Rose and Rhonda Patrick. Phospholipid form
20g collagen with 1000mg Vitamin C. Based on Keith Baar's research for connective tissue support during recovery
Tissue repair peptide. Recent addition for elbow surgery recovery. Not medical advice - for information only
Tissue repair peptide. Recent addition for elbow surgery recovery. Not medical advice - for information only
5mg elemental lithium for mood stabilization and neuroprotection. Low-dose, non-prescription form